Role of IL-17 in Glioma Progression

Paradoxical Role of IL-17 in Progression of Diabetic Nephropathy.

Diabetic nephropathy (DN) is the most common cause of ESRD in the United States. Current standard of care for patients with DN can slow the progression of DN, but there are no effective therapies to halt progression of established DN. The lack of more effective therapies in established DN is in part because the underlying mechanisms involved in its progression are not fully understood. Therefor...

The Role of IL-23/IL-17 Axis in Lupus

Leishmaniasis in Susceptible Mice IL-17 Promotes Progression of Cutaneous

Functional IL-17R in glioma stem cells: potential role in tumor progression and therapeutic implications

Interleukin 17 (IL-17) is one of the most potent inflammatory cytokines and has been strongly implicated in inflammatory autoimmune disorders like rheumatoid arthritis and multiple sclerosis. However, the role of IL-17 in tumor progression is quite controversial and the underlying mechanisms remain largely unknown. Our group and others have recently reported the prevalence of IL-17 secreting ce...

IL-17 and IL-4 Producing CD8+ T Cells in Tumor Draining Lymph Nodes of Breast Cancer Patients: Positive Association with Tumor Progression

Background: CD8+ cytotoxic T lymphocytes have been recently divided based on their cytokine expression profile. Objective: To evaluate the percentages of CD8+ lymphocytes and their effector subsets including Tc1, Tc2 and Tc17 in the tumor draining lymph nodes (TDLNs) of patients with breast cancer. Methods: Single cell suspensions were obtained from TDLNs of 42 patients with breast cancer. Stai...